Vol. 7, Issue 2, Part G (2025)

Background: Dengue is the most important vector-borne viral infection worldwide. Due to its variable clinical presentation, identifying factors associated with progression to severe disease is crucial. The objective was to determine clinical and paraclinical factors associated with severe dengue in adults. 
Methods: A retrospective cross-sectional study was conducted on 149 adult patients diagnosed with dengue at a General Hospital in Oaxaca, Mexico. Data on age, sex, BMI, comorbidities, and hematological parameters were analyzed. Patients were classified into severe and non-severe dengue groups. 
Results: Of 149 patients, 9.4% presented with severe dengue. Significant risk factors for severity included advanced age (p = 0.006), chronic kidney disease (p = 0.04), elevated hemoglobin (p = 0.01), and leukocytosis (p = 0.01). Diabetes and hypertension were frequent but not statistically associated with severity in this cohort.
Conclusions: Advanced age, chronic kidney disease, and elevated hemoglobin and leukocyte levels are significant predictors of severe dengue in adults. Early identification of these markers can optimize therapeutic management.