Vol. 7, Issue 2, Part D (2025)

Background: Pseudomonas aeruginosa is an aerobic gram negative rod which is widely implicated in skin and soft tissue infections. It is also one of the most important cause of hospital acquired infections. Development of Antimicrobial resistance in Pseudomonas is a very big concern as it poses difficulty in treating infections 
Aim: The aim of this study is to analyse antimicrobial susceptibility of Pseudomonas aeruginosa isolated specifically from skin and soft tissue infections for a period of 3 months in a tertiary care hospital. The study also focuses on Carbapenems’ (Imipenem, Meropenem) resistance of Pseudomonas aeruginosa.
Materials & Methods: Antimicrobial susceptibility testing of Pseudomonas aeruginosa isolated from (207) wound swab and pus samples from both inpatient and outpatient samples are done by Kirby Bauer disc diffusion method and interpreted as per CLSI (Clinical Laboratory Standard Institute) guidelines.
Results: In this study, Majority of the Pseudomonas isolates are susceptible to Piperacillin-tazobactam (91%) Imipenem (89%), Meropenem (91%). A comparatively lesser percentage of susceptibility is seen towards cephalosporins and fluroquinolones. Maximum Percentage of Pseudomonas isolates were obtained from Burn Intensive Care unit (48.3%).Percentage of Pseudomonas isolates resistance to Imipenem, Meropenem are 9%, 12% respectively.
Conclusion: Pseudomonas is gaining resistance to various group of antibiotics especially cephalosporins and fluroquinolones. It has also started slowly gaining resistance to Carbapenem group of antibiotics.