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International Journal of Research in Medical Science

Vol. 6, Issue 2, Part A (2024)

Molecular basis of vascular pathology in rheumatoid is it reasonable?

Author(s):

Jamal Naser Farhood

Abstract:

Objectives: Analyze HLA DRB1 genotype of rheumatoid arthritis patients using PCR-SSP analysis, concurrently measuring levels of P-ANCA vasculits markers using indirect ELIZA and trying to elucidate if there is any genetic basis.

Study protocol: This is a prospective cohort study comprised of 110 subjects (102 females and 8 males), with an age range of 24-71 years (average 45.6±12.245) fulfilling the American College of Rheumatology (ACR) criteria for RA. Blood samples were taken from all members of the study groups (110 RA patients and 50 healthy controls), and subsequently tested for HLA-DRB1 genetic analysis using PCR-SSP and P-ANCA using indirect ELIZA.

Results: DRB1 alleles (*10 and*15) showed higher frequency percentage in anti-cathepsin G positive patients, though non –significant. On the other hand, a particular allele (HLA-DRB*7) was found in higher proportion in rheumatoid patients with positive anti-lactoferrin autoantibodies. All HLA DRB1 allele groups (except *04 and *10) were found in a higher frequency in anti-elastase positive.

Conclusion: Possible role of non-shared epitope DRB alleles in severity of RA patients.

Pages: 41-44  |  167 Views  47 Downloads


International Journal of Research in Medical Science
How to cite this article:
Jamal Naser Farhood. Molecular basis of vascular pathology in rheumatoid is it reasonable?. Int. J. Res. Med. Sci. 2024;6(2):41-44. DOI: 10.33545/26648733.2024.v6.i2a.71