Eman Abid Fahad Alhasnawi, Iman Khdheir Diwen and Mohammed Fouad Saleh
Epstein Barr Virus (EBV), is associate to the Herpesviridae family, revealed as a corporate pathogen within human viral infections, in addition representation an important source in the progress of many types of cancers, influencing global health troubles. So, this review searches in association of EBV’s with cancer development by probing its molecular mechanisms, epidemiological styles, besides correlated malignancy disorders. Many studies showed that EBV is thoroughly associated to lymphatic tumors such as “Burkitt lymphoma and Hodgkin lymphoma, as well as with epithelial malignant tumors similar to a nasopharyngeal carcinoma in addition to gastric carcinoma”. This virus shows a notable capability to modify functions within the host cellular system, by avoiding the immune response recognition, then activate the genomic variability, which give its oncogenic possibility. Furthermore, within distinction in the frequency of EBV correlated cancers through various body sites, this approve the stimulus power of genetic and environmental factors on disease progress. Recently the improvements in cure management, as well as including the immunotherapy and applying of biomarkers for prompt revealing and diagnosis, afford a novel prospects for management of these cancers. Also this review outlines promising capable research guidelines, that fixing the vaccine advance and originally applications of therapeutic methods which directed and targeted at decreasing and prevent the worldwide effect and control of EBV related and connected with malignant tumor.
Pages: 120-129 | 21 Views 7 Downloads